AustralieFrV1, Main, Exploration, bibRecord, 00A582

Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors : A european organisation for research and treatment of cancer-italian sarcoma group-australasian gastrointestinal trials group study

Identifieur interne : 00A582 ( Main/Exploration ); précédent : 00A581; suivant : 00A583

Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors : A european organisation for research and treatment of cancer-italian sarcoma group-australasian gastrointestinal trials group study

Auteurs : Martine Van Glabbeke [Belgique, Pays-Bas, Italie, France, Allemagne, Australie, Royaume-Uni] ; Jaap Verweij ; Paolo G. Casali ; Axel Le Cesne ; Peter Hohenberger ; Isabelle Ray-Coquard ; Marcus Schlemmer ; Allan T. Van Oosterom ; David Goldstein ; Raf Sciot ; Pancras C. W. Hogendoorn ; Michelle Brown ; Rossella Bertulh ; Ian R. Judson

Source :

Journal of clinical oncology [ 0732-183X ] ; 2005.

RBID : Pascal:05-0450872

Descripteurs français

Pascal (Inist)
- Imatinib, Tardif, Résistance, Sarcome, Protein-tyrosine kinase, Inhibiteur enzyme, Facteur prédictif, Pronostic, Europe, Recherche, Traitement, Italie, Australasie, Essai clinique, Cancérologie, Anticancéreux, Tumeur stromale gastrointestinale, Cancer gastrointestinal.
Wicri :
- geographic : Italie.
- topic : Recherche.

English descriptors

KwdEn :
- Antineoplastic agent, Australasia, Cancerology, Clinical trial, Enzyme inhibitor, Europe, Gastrointestinal cancer, Gastrointestinal stromal tumor, Imatinib, Italy, Late, Predictive factor, Prognosis, Protein-tyrosine kinase, Research, Resistance, Sarcoma, Treatment.

Abstract

Purpose The aim of this study was to identify factors predicting initial and late resistance of Gl stromal tumor (GIST) patients to imatinib and to document the dose-response relationship in the prognostic subgroups This study is based on the European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group randomized trial comparing two doses of imatinib in advanced disease Patients and Methods Initial resistance was defined as progression within 3 months of randomization, and late resistance was defined as progression beyond 3 months Investigated cofactors include imatinib dose, age, sex, performance status, original disease site, site and size of lesions at trial entry, and baseline hematologic and biologic parameters. Results Initial resistance was recorded for 116 (12%) of 934 assessable patients and was independently predicted by the presence of lung and absence of liver metastases, low hemoglobin level, and high granulocyte count Among 818 patients who were alive and progression free at 3 months, 347 subsequent progressions were recorded, and late resistance was independently predicted by high baseline granulocyte count, primary tumor outside of the stomach, large tumor size, and low initial imatinib dose The impact of initial dose on late resistance was mainly significant in patients with a high baseline granulocyte count (> 5 10⁹/L) and in patients with tumors of Gl origin outside of the stomach and small intestine Conclusion Our study identifies patients for whom initial and/or long-term treatment needs to be improved and patients who require a high initial dose. Correlation of these results with immunohistochemistry and molecular parameters may further help to understand the biologic mechanisms of resistance.

Affiliations:

Allemagne, Australie, Belgique, France, Italie, Pays-Bas, Royaume-Uni
Angleterre, Auvergne-Rhône-Alpes, Bavière, Berlin, District de Haute-Bavière, Grand Londres, Hollande-Méridionale, Rhône-Alpes, Région de Bruxelles-Capitale
Berlin, Bruxelles, Leyde, Londres, Lyon, Munich, Rotterdam

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 004723
to stream PascalFrancis, to step Curation: 001980
to stream PascalFrancis, to step Checkpoint: 004544
to stream Main, to step Merge: 00B194
to stream Main, to step Curation: 00A582

Le document en format XML

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<term>Australasia</term>
<term>Cancerology</term>
<term>Clinical trial</term>
<term>Enzyme inhibitor</term>
<term>Europe</term>
<term>Gastrointestinal cancer</term>
<term>Gastrointestinal stromal tumor</term>
<term>Imatinib</term>
<term>Italy</term>
<term>Late</term>
<term>Predictive factor</term>
<term>Prognosis</term>
<term>Protein-tyrosine kinase</term>
<term>Research</term>
<term>Resistance</term>
<term>Sarcoma</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Imatinib</term>
<term>Tardif</term>
<term>Résistance</term>
<term>Sarcome</term>
<term>Protein-tyrosine kinase</term>
<term>Inhibiteur enzyme</term>
<term>Facteur prédictif</term>
<term>Pronostic</term>
<term>Europe</term>
<term>Recherche</term>
<term>Traitement</term>
<term>Italie</term>
<term>Australasie</term>
<term>Essai clinique</term>
<term>Cancérologie</term>
<term>Anticancéreux</term>
<term>Tumeur stromale gastrointestinale</term>
<term>Cancer gastrointestinal</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term>
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<front><div type="abstract" xml:lang="en">Purpose The aim of this study was to identify factors predicting initial and late resistance of Gl stromal tumor (GIST) patients to imatinib and to document the dose-response relationship in the prognostic subgroups This study is based on the European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group randomized trial comparing two doses of imatinib in advanced disease Patients and Methods Initial resistance was defined as progression within 3 months of randomization, and late resistance was defined as progression beyond 3 months Investigated cofactors include imatinib dose, age, sex, performance status, original disease site, site and size of lesions at trial entry, and baseline hematologic and biologic parameters. Results Initial resistance was recorded for 116 (12%) of 934 assessable patients and was independently predicted by the presence of lung and absence of liver metastases, low hemoglobin level, and high granulocyte count Among 818 patients who were alive and progression free at 3 months, 347 subsequent progressions were recorded, and late resistance was independently predicted by high baseline granulocyte count, primary tumor outside of the stomach, large tumor size, and low initial imatinib dose The impact of initial dose on late resistance was mainly significant in patients with a high baseline granulocyte count (> 5 10<sup>9</sup>
/L) and in patients with tumors of Gl origin outside of the stomach and small intestine Conclusion Our study identifies patients for whom initial and/or long-term treatment needs to be improved and patients who require a high initial dose. Correlation of these results with immunohistochemistry and molecular parameters may further help to understand the biologic mechanisms of resistance.</div>
</front>
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<name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
<name sortKey="Van Oosterom, Allan T" sort="Van Oosterom, Allan T" uniqKey="Van Oosterom A" first="Allan T." last="Van Oosterom">Allan T. Van Oosterom</name>
<name sortKey="Verweij, Jaap" sort="Verweij, Jaap" uniqKey="Verweij J" first="Jaap" last="Verweij">Jaap Verweij</name>
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<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="Italie"><noRegion><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="France"><noRegion><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="Allemagne"><region name="Berlin"><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="Australie"><noRegion><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Van Glabbeke, Martine" sort="Van Glabbeke, Martine" uniqKey="Van Glabbeke M" first="Martine" last="Van Glabbeke">Martine Van Glabbeke</name>
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EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00A582 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:05-0450872
   |texte=   Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors : A european organisation for research and treatment of cancer-italian sarcoma group-australasian gastrointestinal trials group study
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors : A european organisation for research and treatment of cancer-italian sarcoma group-australasian gastrointestinal trials group study

Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors : A european organisation for research and treatment of cancer-italian sarcoma group-australasian gastrointestinal trials group study

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